Neonatal Lupus Erythematosus Manifests as Pancytopenia and Mildly Abnormal Liver Functions.
- Author:
Seung Min LEE
1
;
Soon Shik HAM
;
In Sang JEON
;
Dong Woo SON
Author Information
1. Department of Pediatrics, Gachon Medical School, Incheon, Korea. isjeon@gilhospital.com
- Publication Type:Case Report
- Keywords:
Neonatal lupus erythematosus;
Pancytopenia;
Anti-Ro antibody
- MeSH:
Autoantibodies;
Autoimmune Diseases;
Exanthema;
Humans;
Infant;
Infant, Newborn;
Liver*;
Mothers;
Pancytopenia*
- From:Korean Journal of Perinatology
2005;16(4):317-321
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro or anti-La maternal autoantibodies. The cutaneous lupus lesions are commonly observed and usually resolve spontaneously. The cardiac involvement which sometimes needs the permanent pacemaker, however, is the most clinically significant manifestation of NLE. In addition, the hepatic and hematologic abnormalities are observed in approximately 10% of infants with NLE. Therefore, in the way of the evaluation of hematologic disorders in neonate, NLE should be included. We present a case of NLE in an infant born to a mother with anti-Ro, and he had skin rash, pancytopenia and mildly abnormal liver functions without cardiac manifestation.
