Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice.
- Author:
Zi-jun CHEN
1
;
Yun-sen LI
;
Ji-yan ZHOU
;
Zheng-tao WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cytokines; metabolism; Diterpenes, Kaurane; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Interferon-gamma; metabolism; Interleukin-2; metabolism; Interleukin-4; metabolism; Interleukin-5; metabolism; Isodon; chemistry; Male; Mice; Mice, Inbred BALB C; Plants, Medicinal; chemistry; Th1 Cells; metabolism; Th2 Cells; metabolism; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2006;31(15):1257-1260
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.
METHODBy using flow cytometer with CBA software to detect Th1/Th2 type cytokines.
RESULTGLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.
CONCLUSIONImmunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.
