Preparation of Shuxiong micropellets by centrifugal granulation technology.
- Author:
Hong-Tao SONG
1
;
Qian ZHANG
;
Lu-Ling KONG
;
Da-Wei CHEN
;
Zhong-Gui HE
Author Information
- Publication Type:Journal Article
- MeSH: Carthamus tinctorius; chemistry; Cellulose; Centrifugation; methods; Chalcone; administration & dosage; analogs & derivatives; isolation & purification; Drug Combinations; Excipients; Ginsenosides; administration & dosage; isolation & purification; Hypromellose Derivatives; Ligusticum; chemistry; Methylcellulose; analogs & derivatives; Microspheres; Panax notoginseng; chemistry; Particle Size; Phenols; administration & dosage; isolation & purification; Plants, Medicinal; chemistry; Quinones; administration & dosage; isolation & purification; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2006;31(14):1147-1150
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare shuxiong micropellets.
METHODShuxiong micropellets were prepared by using a centrifugal granulator. The formulation composition and process factors were optimized investigated by adopting several indices such as size distribution, repose angle, bulk density and friability as indexes.
RESULTThe optimal process parameters were as follows. The ratio of fine intermediate product and MCC was 3:1 (w/w), the adhesive agent was 3% HMPC solution, the rotating rate of plate was 200 r x min(-1), the blower rate was 15 x 20 L x min(-1), the rate of air flow was 15 L x min(-1), the spray air pressure was 0.5 MPa, the rotating of spray solution pump was 5-25 r x min(-1) and the rotating rate of powder feed machine was 5-25 r x min(-1).
CONCLUSIONUnder the optimal conditions, micropellets prepared by using centrifugal granulator hadpossessed prefect shape and surface characteristics and the yield of shuxiong pellets was 90.5%.
