Effects of Siwu decoction on bone marrow protein expression of blood deficiency mice induced by cyclophosphamide.
- Author:
Li-Li LIU
1
;
Zeng-Chun MA
;
Yu-Guang WANG
;
Hong-Lin QIN
;
Hong-Ling TAN
;
Cheng-Rong XIAO
;
Yue GAO
Author Information
- Publication Type:Journal Article
- MeSH: Actin Depolymerizing Factors; metabolism; Anemia; chemically induced; metabolism; pathology; Animals; Annexin A1; metabolism; Apoptosis; drug effects; Carbonic Anhydrases; metabolism; Cell Differentiation; drug effects; Cell Proliferation; drug effects; Cyclophosphamide; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fatigue; chemically induced; metabolism; pathology; Female; Hematopoietic Stem Cells; metabolism; pathology; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Peroxidases; metabolism; Peroxiredoxins; Plants, Medicinal; chemistry; Proteome; metabolism; Proteomics; methods
- From: China Journal of Chinese Materia Medica 2006;31(14):1172-1175
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Siwu decoction on protein expression of blood deficiency mice induced by cyclophosphamide (CIX) and discuss the possible molecular mechanism on blood enriching function of Siwu decoction.
METHODBlood deficiency mice were established by injecting ip with 250 mg x kg(-1) CTX. Proteomic technologies were applied to identify the different protein.
RESULTSiwu decoction could restore the changes of 12 up-regulated and 3 down-regulated proteins in bone marrow of blood deficiency mice induced by cyclosphosphamide.
CONCLUSIONSiwu decoction could effect expression of proteins which functions including apoptosis, proliferation and differentiation of the haematopoietic stem/progenitor cell. The regulation in the molecular level might be the mechanism of stimulating hematopoiesis in bone marrow fo siwu decocetion.
