Antivirus effects of extract from gardenia.
- Author:
Yi-Zhong WANG
1
;
Xiao-Lan CUI
;
Ying-Jie GAO
;
Shan-Shan GUO
;
Xiu-Kun WANG
;
Yang HUANG
;
Ye ZHAO
;
Weng-Feng GONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antiviral Agents; pharmacology; Cells, Cultured; Drugs, Chinese Herbal; isolation & purification; pharmacology; Epithelial Cells; cytology; virology; Esophagus; cytology; virology; Female; Gardenia; chemistry; Herpesvirus 1, Human; drug effects; Humans; Influenza A Virus, H1N1 Subtype; drug effects; Male; Mice; Nitric Oxide; blood; Orthomyxoviridae; pathogenicity; Plants, Medicinal; chemistry; Pneumonia, Viral; blood; drug therapy; Random Allocation; Respiratory Syncytial Virus, Human; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(14):1176-1178
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of the extract from gardenia on influenza viral pneumonia in mice and virus-induced cytopathic effect.
METHODThe mice were infected by influenza virus in nasal, the lung inflammation, mortality rate and life elongation rate were observed respectively. The anti-viral activity of the extract from gardenia was accessed by cytopathic effect (CPE) in vitro and 0% toxicity concentration (TC0), 50% toxicity concentration (TC50), 50% inhibitor concentration (IC50), therapeutic index (TI) were determined by Reed-Muench method.
RESULTThe pneumonia induced by influenza virus in mice was inhibited significantly by the extract from gardenia, as the mortality rate decreased and the life elongation rate increased remarkably. Meanwhile the NO content in serum decreased significantly; The cytopathic effect induced by six kinds of viruses was inhibited remarkably.
CONCLUSIONThe six kinds of viruses were inhibited significantly by the extract from gardenia which inhibitory effect on mice influenza viral pneumonia was related to the NO content decreased.
