Study on antioxidant activity of pigment of Lycium ruthenicum.
- Author:
Jin LI
1
;
Wei-Jing QU
;
Su-Jun ZHANG
;
Hai-Ying LV
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; pharmacology; Biphenyl Compounds; metabolism; Erythrocytes; drug effects; Free Radical Scavengers; pharmacology; Hemolysis; drug effects; Hydrazines; metabolism; Lipid Peroxidation; drug effects; Liver; metabolism; Lycium; chemistry; Malondialdehyde; metabolism; Mice; Mitochondria, Liver; pathology; Mitochondrial Swelling; drug effects; Phenols; isolation & purification; pharmacology; Picrates; Pigments, Biological; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Reactive Oxygen Species
- From: China Journal of Chinese Materia Medica 2006;31(14):1179-1183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo elvaulate the antioxidant activity of the pigment of Lycium ruthenicum.
METHODThe antioxidant activities were measured by the effects of the reducing ability, scavenging DPPH. H2O2-induced hemolysis of mice erythrocyte, serum resistance of reactive oxygen species, content of MDA in liver tissue, and swelling effect of mitochondria in liver tissue.
RESULTThe pigment of L. ruthenicum could scaveng DPPH* remarkably with IC50 0.164 mg x mL(-1), inhibitte hemolysis of mice erythrocyte evidently with IC50 0.112 mg x mL(-1). The resistant of reactive oxygen species was enhanced by the tested substances, simultanously. The concentration of MDA of peroxidation of lipid in mice liver could be reduced, and the swelling of mice liver mitochondria alse be restrained.
CONCLUSIONThe pigment of L. ruthenicum has antioxidant activity in tested concentration.
