Virological characterization of influenza A(H3N2) virus in Mainland China during 2011-2012.
- Author:
Wei-Juan HUANG
1
;
Yan-Hui CHENG
;
Xi-Yan LI
;
Xiang ZHAO
;
Jun-Feng GUO
;
Zhao WANG
;
Min-Ju TAN
;
Ming LI
;
Hong-Tao SUI
;
He-Jiang WEI
;
Yao-Yao CHEN
;
Ning XIAO
;
Yu LAN
;
Da-Yan WANG
;
Yue-Long SHU
Author Information
1. Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, WHO Collaborating Center for Reference and Research on Influenza, Beijing 102206, China. huangweijuan@cnic.org.cn
- Publication Type:Journal Article
- MeSH:
Amino Acid Sequence;
China;
epidemiology;
Hemagglutinin Glycoproteins, Influenza Virus;
chemistry;
genetics;
Humans;
Influenza A Virus, H3N2 Subtype;
classification;
genetics;
isolation & purification;
physiology;
Influenza, Human;
epidemiology;
virology;
Models, Molecular;
Molecular Sequence Data;
Phylogeny
- From:
Chinese Journal of Virology
2013;29(3):258-264
- CountryChina
- Language:Chinese
-
Abstract:
To study the prevalence and variation of influenza A(H3N2) viruses, the antigenic and genetic characteristics of influenza A(H3N2) viruses circulating in Mainland China during April 2011 to March 2012 were analyzed. The results showed that influenza A(H3N2) viruses increased gradually since 2012 and became the dominant strain since March. The viruses were antigenically closely related to the vaccine strain A/PER/16/09 (87.2%) and the representative virus A/FJ/196/09 (76.0%) in Mainland China. The genetic characteristics analysis results showed that recently isolated viruses belonged to the Vic/208 clade, and most of the low reaction strains also fell into the same clade. Crystal structure analysis of HA protein found that, compared with the vaccine strain A/PER/16/09, the recently isolated viruses had amino acid substitutions in the antigenic site A, B and C areas, in addition to gaining potential glycosylation sites at the amino acid position of 45 of HA and 367 of NA. Although the majority of circulating influenza A (H3N2) viruses in 2011-2012 season in Mainland China were antigeniclly matched by current influenza vaccine strain and the selected representative viruses, low reaction strains have increased since 2012, therefore it is necessary to strengthen the surveillance on the variation of influenza virus and to provide solid information for the vaccine strain selection.
