Chemical modification of recombinant adenovirus-associated virus vectors.
- Author:
Dan ZHANG
1
;
Fei QIU
2
;
Yong DIAO
2
Author Information
1. Institutes of Molecular Medicine, Huaqiao University, Quanzhou 362021, China. learner_near@163.com
2. Institutes of Molecular Medicine, Huaqiao University, Quanzhou 362021, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Chemical Phenomena;
Chemistry;
methods;
Dependovirus;
chemistry;
genetics;
metabolism;
Gene Transfer Techniques;
Genetic Vectors;
chemistry;
genetics;
metabolism;
Humans
- From:
Chinese Journal of Virology
2013;29(5):566-572
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant adenovirus-associated virus (rAAV) vectors mediated gene delivery system has been widely used in the treatments of cancer or other genetic diseases. It is considered to be one of the most promising vector owing to its non-pathogenicicity, low immune response, potential to integrate site-specif-ically, persistent and stable gene expression. However, it was limited in clinical applications because it is easy to be neutralized in serum and non-selection to the target site. Chemical modifications of rAAV have been studied to overcome those problems. This article reviewed the progress of chemical modifications of rAAV by various compounds and different modification methods, and predicted what the researches needed to do in the future.
