Recent progress on SELEX and its applications.
- Author:
Shao-bing ZHAN
1
;
Yi ZENG
2
Author Information
1. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. zhanboyang@sina.com
2. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Gene Library;
Humans;
Oligonucleotides;
genetics;
SELEX Aptamer Technique;
methods
- From:
Chinese Journal of Virology
2013;29(5):573-577
- CountryChina
- Language:Chinese
-
Abstract:
SELEX technology (Systematic Evolution of Ligand by Exponential Enrichment) is a new in vitro screening technology appeared and developed in the past 20 years. SELEX integrate library technology and screening techniques, screening a nucleic acid molecule from nucleic acid library by ligand-aptamer interaction. Similar to the antibodies, aptamers bind with the specific target substance. SELEX screening technology develops rapidly, and aptamer have been widely applied in biomedical field. This article briefly-overviewed the progress and its applications of SELEX technology in recent years.
