Progress on mechanism of cell apoptosis induced by rubella virus.
- Author:
Zhen-mei LI
1
;
Fu-lu CHU
2
;
Ying LIU
2
;
Zhi-yu WANG
2
Author Information
1. Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China. meizi_chongzi@163.com
2. Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Humans;
MAP Kinase Signaling System;
Mitogen-Activated Protein Kinases;
genetics;
metabolism;
Rubella;
genetics;
metabolism;
physiopathology;
virology;
Rubella virus;
genetics;
physiology
- From:
Chinese Journal of Virology
2013;29(5):578-582
- CountryChina
- Language:Chinese
-
Abstract:
Rubella virus (RV), a member of the family Togaviridae, can induce apoptosis of host cells in vitro. Protein kinases of the Ras-Raf-MEK-ERK pathway and PI3K-Akt pathway play essential roles in virus multiplication, cell survival and apoptosis. Proteins p53 and TAp63 that bind to specific DNA sequences stimulate Bax in a manner to produce functional pores that facilitate release of mitochondrial cytochrome c and downstream caspase activation. In this review, the molecular mechanisms of RV-induced cell apoptosis, including RV-infected cell lines, pathological changes in cell components and apoptosis signaling pathways are summarized.
