Progress on host range factors and their mechanisms of poxvirus.
- Author:
Gang BAI
1
;
Huai-Jie JIA
2
;
Xiao-Bing HE
2
;
Zhi-Zhong JING
2
Author Information
1. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agricultural Ministry, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China. baig.love@163.com
2. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agricultural Ministry, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Host Specificity;
Host-Pathogen Interactions;
Humans;
Poxviridae;
classification;
genetics;
isolation & purification;
physiology;
Poxviridae Infections;
veterinary;
virology;
Viral Proteins;
genetics;
metabolism
- From:
Chinese Journal of Virology
2013;29(6):655-661
- CountryChina
- Language:Chinese
-
Abstract:
Poxvirus is one of the most serious zoonosis pathogens, which has largest genome and broadest host spectrum. With the development of molecular biology, functional genomics, and immunology-related technology, the interactions between pathogen and the host, particularly a large array of host range factors and their functions have been increasingly discovered. These findings provide references for the molecular basis of poxvirus tissue tropism and host specificity. This review focus on the introduction of host range factors in major members of Chordopoxvirinae to highlight the understanding of the mechanisms of molecular genetic evolution, the host tropism, and cross-species infection of poxviruses.
