Advances in research and development of universal influenza vaccines.
- Author:
Li-Xia ZHANG
;
Jian-Fang ZHOU
;
Yue-Long SHU
;
Bao-Shou YANG
;
Zhao-Qing HE
- Publication Type:Journal Article
- MeSH:
Animals;
Cross Reactions;
Humans;
Orthomyxoviridae;
immunology;
Species Specificity;
Viral Proteins;
immunology;
Viral Vaccines;
genetics;
immunology
- From:
Chinese Journal of Virology
2014;30(1):73-78
- CountryChina
- Language:Chinese
-
Abstract:
Vaccination is the primary strategy for the prevention and control of pandemic influenza. Because influenza virus is highly variable across strains, universal influenza vaccines need to be developed to address this problem. This review describes the research progress in conserved epitopes of influenza virus, the advances in the research and development of universal influenza vaccines based on the relatively conserved sequences of NP, M2e, HA2, and headless HA, the mechanisms of cross-protection, and the methods to improve cross-protection.
