Research progress in human enterovirus recombination.
- Author:
Hai-Yan WANG
;
Ping JIANG
;
Peng CHEN
;
Ze-Xin TAO
;
Wen-Qiang ZHANG
;
Ai-Qiang XU
- Publication Type:Journal Article
- MeSH:
Animals;
Biomedical Research;
trends;
Enterovirus;
classification;
genetics;
Enterovirus Infections;
virology;
Humans;
Recombination, Genetic;
Viral Proteins;
genetics
- From:
Chinese Journal of Virology
2014;30(2):180-187
- CountryChina
- Language:Chinese
-
Abstract:
Complex genetic variation has been known to occur during the transmission of human enterovirus (HEV), and the HEV virulence and pathogenicity enhanced by genetic recombination also pose a serious threat to human health. In recent years, the interest in recombination mechanism of genetic plasticity has been renewed with the emergence of pathogenic recombinant circulating vaccine-derived polioviruses, which were implicated in poliomyelitis outbreaks in several regions of the world with insufficient vaccination coverage. This paper reviews recent research progress in HEV genome, including evolutionary characteristics, recombination types, and in vitro recombinant construction.
