Advances in reverse genetics-based vaccines of foot and mouth disease.
- Author:
Bo YANG
;
Fan YANG
;
Song-Hao WANG
;
Yan ZHANG
;
Wei-Jun CAO
;
Hong YIN
;
Hai-Xue ZHENG
- Publication Type:Journal Article
- MeSH:
Animals;
Antibodies, Viral;
immunology;
Foot-and-Mouth Disease;
immunology;
prevention & control;
virology;
Foot-and-Mouth Disease Virus;
genetics;
immunology;
Reverse Genetics;
Viral Vaccines;
genetics;
immunology
- From:
Chinese Journal of Virology
2014;30(2):213-220
- CountryChina
- Language:Chinese
-
Abstract:
Reverse-genetic engineering of foot and mouth disease virus (FMDV) can improve the productivity, antigen matching, antigen stability, immune response ability, and biological safety of vaccines, so vaccine candidates with anticipated biological characteristics can be promptly achieved. Negative influence in taming of virulent strains can also be decreased or avoided. Reverse genetics not only make up for deficiencies like limitation of viral nature, low success rate, and time and energy consuming, but also realize more active designing of vaccines. Therefore, reverse genetics is significant in improving integral quality and efficiency of vaccines. In this review, we use FMDV vaccines as an example to summarize improvement in biological characteristics of virulent strains and provide a reference for related researches.
