Comparison of New Onset Diabetes according to the Time of Onset in Kidney Transplant Recipients.
10.4285/jkstn.2009.23.2.149
- Author:
Kyu Jong YOON
1
;
Jun Ho PARK
;
Doo Jin KIM
;
Sung Gil PARK
;
Jeong Hoon LEE
;
Joo Seop KIM
;
Suk Ja HYUN
;
Samuel LEE
Author Information
1. Department of Surgery, University of Hallym College of Medicine, Seoul, Korea. slee@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Renal transplantation;
Post-transplantation diabetes mellitus;
Risk factor
- MeSH:
Diabetes Mellitus;
Glucose;
Humans;
Kidney;
Kidney Transplantation;
Medical Records;
Retrospective Studies;
Risk Factors;
Tacrolimus;
Transplants
- From:The Journal of the Korean Society for Transplantation
2009;23(2):149-153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: New onset diabetes is a common complication after kidney transplantation. However, the clinical course of post-transplant diabetes mellitus (PTDM) remains unclear. The aim of the present study is to analyze the natural courses and risk factors of PTDM according to the time of onset. METHODS: A total of 216 consecutive kidney transplant recipients were enrolled and patient medical records were investigated retrospectively. PTDM was defined as glucose > or =126mg without previous diabetic history. Patients were classified according to the onset (12 months): early PTDM (E-PTDM) and late PTDM (L-PTDM). RESULTS: PTDM was observed in 34 (17.4%) patients. The number of E-PTDM and L-PTDM patients was 17 and 17. Compared with normoglycemic patients, the PTDM group was older and showed higher pre-transplant HbA1c level. The use of tacrolimus was associated with the development of E-PTDM (OR=4.87, 1.71~13.8 in 95% CI) but not L-PTDM (OR=0.34, 0.04~2.70 in 95% CI) CONCLUSIONS: The development of E-PTDM and L-PTDM may have different risk factors. It will be important to choose different therapeutic strategy according to the onset of PTDM.
