Effects of rhG-CSF on T cell during peripheral blood stem/progenitor cell mobilization and its mechanisms--review.
- Author:
Wen-Rong HUANG
1
;
Wan-Ming DA
Author Information
1. Department of Hematology, General Hospital of PLA, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Blood Donors;
Granulocyte Colony-Stimulating Factor;
pharmacology;
therapeutic use;
Hematopoietic Stem Cell Mobilization;
methods;
Humans;
Interleukin-10;
biosynthesis;
Recombinant Proteins;
Suppressor of Cytokine Signaling 3 Protein;
Suppressor of Cytokine Signaling Proteins;
biosynthesis;
T-Lymphocytes;
cytology;
drug effects;
metabolism
- From:
Journal of Experimental Hematology
2005;13(2):338-342
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant human granulocyte-colony-stimulating factor (rhG-CSF) can widely regulate human immunologic response. In the protocol of peripheral blood stem/progenitor cell mobilization, rhG-CSF can change the numbers and functions of T cells. Then the results can impact the incidence of graft-versus-host disease after allogeneic peripheral blood stem/progenitor cell transplantation. The regulation of rhG-CSF on T cell is an indirect action which is based on the direct action to monocytes and dendritic cells. The numerous IL-10 secreted by monocytes plays a key role in cytokines production, proliferative response and cytotoxicity of T cells. Endogenous IL-10 can induce high expression of SOCS3 and the SOCS3 is very important for regulating the signal transduction of the activities of T cells. In this review influences of rhG-CSF on T-cells in mobilization process and related mechanisms were elaborated with emphasis.
