HOXB gene family and functions of hematopoietic stem/progenitor cells--review.
- Author:
Yu-Hong TANG
1
;
Cheng-Ya WANG
Author Information
1. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. yuhongtang@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Hematopoiesis;
genetics;
immunology;
physiology;
Hematopoietic Stem Cells;
cytology;
immunology;
metabolism;
Homeodomain Proteins;
genetics;
physiology;
Humans;
Multigene Family
- From:
Journal of Experimental Hematology
2005;13(2):343-347
- CountryChina
- Language:Chinese
-
Abstract:
Recently, many researches indicated the important role played by homeobox (HOX) gene family in normal hematopoiesis. As a kind of transcription factors, HOX gene products regulate and control the expression of target genes by binding to special DNA sequences. HOXB, a member of HOX gene family, especially HOXB(4), interests people greatly. It has been found that its expression relates closely to the self-renewal of hematopoietic stem cells and effective proliferation of hematopoietic progenitor cells. This review presents some new research progress in this area.
