Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia.
- Author:
Lei TIAN
1
;
Ling-Bo LIU
;
Xiao-Bei WANG
;
Juan XIAO
;
Ping ZOU
Author Information
1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Antigens, CD34;
analysis;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Bone Marrow Transplantation;
CD13 Antigens;
analysis;
Chromosome Banding;
Chromosomes, Human, Pair 8;
genetics;
Female;
Flow Cytometry;
HLA-DR Antigens;
analysis;
Humans;
Immunophenotyping;
Karyotyping;
Leukemia, Monocytic, Acute;
genetics;
immunology;
therapy;
Leukemia, Myelomonocytic, Acute;
genetics;
immunology;
therapy;
Male;
Middle Aged;
Peripheral Blood Stem Cell Transplantation;
Prognosis;
Trisomy
- From:
Journal of Experimental Hematology
2005;13(3):364-368
- CountryChina
- Language:English
-
Abstract:
To evaluate the impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia (M(4), M(5)), a total of 56 cases of acute myelomonocytic and monocytic leukemia were investigated. Karyotypes were analyzed by G-banding or R-banding. The immunotypes in all cases were detected by flow cytometry. And the clinical characteristics at the first visit were analyzed retrospectively. The results showed that thirty-four of 56 (60.7%) patients had normal cytogenetics; 10 (17.9%) patients had trisomy 8 in their karyotypes, including 3 (5.4%) patients with trisomy 8 as the sole aberration; and 12 (21.4%) patents had other cytogenetic abnormalities (except trisomy 8). All trisomy 8 cases demonstrated a increased expression frequency of surface markers of myeloid progenitor cells CD34 (P < 0.01) and CD117 (P < 0.05) and a decreased expression frequency of surface markers of mature monocytes CD11c (P < 0.01) and CD14 (P < 0.05), compared with normal cytogenetics cases. Patients with trisomy 8 were slightly older (P < 0.05), which had lower percentages of peripheral blasts (P < 0.05) and lower WBC (P < 0.05) than the patients without trisomy 8. Patients with trisomy 8 had a shorter disease-free survival time than that of patients with normal cytogenetics (P < 0.05). It is concluded that trisomy 8 may play an important role in the pathogenesis and progression of acute myelomonocytic/monocytic leukemia (M(4)/M(5)), whic seems to be related with a block in differentiation of monocytes. Therefore, trisomy 8 may be an adverse prognostic factor for patients with M(4) or M(5).
