A case of hepatosplenic gammadelta T cell lymphoma.
- Author:
Fu-Xu WANG
1
;
Xue-Jun ZHANG
;
Zuo-Ren DONG
Author Information
1. Department of Hematology, The Second Hospital, Hebei Medical University, Shijiazhuang 050000, China. wangfx@hebmu.edu.cn
- Publication Type:Case Reports
- MeSH:
Adult;
Antigens, CD20;
metabolism;
CD2 Antigens;
analysis;
CD3 Complex;
metabolism;
Humans;
Immunohistochemistry;
Ki-1 Antigen;
metabolism;
Liver Neoplasms;
metabolism;
pathology;
Lymphoma, T-Cell;
metabolism;
pathology;
Male;
Receptors, Antigen, T-Cell, gamma-delta;
metabolism;
Splenic Neoplasms;
metabolism;
pathology
- From:
Journal of Experimental Hematology
2005;13(3):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Hepatosplenic gammadelta T cell lymphoma represents rare, often aggressive type of malignant peripheral T-cell lymphoma, which is characterized by expressing T-cell-associated markers CD2, CD3 and gammadelta T-cell receptor, and nonactivated cytotoxic cell phenotype (TIA-1+, granzyme B-). The pathological findings of a liver biopsy specimen revealed the diffuse infiltration of lymphocytes in the sinusoids and the aspiration biopsy from spleen revealed the diffuse infiltration of lymphocytes in the red pulp, not shaped to the nodes, often resulted in the misdiagnosis. Recently, by analyzing the immunophenotype and TCR rearrangement from liver, spleen and bone marrow, a case of adult hepatosplenic gammadelta T cell lymphoma was diagnosed. In combination with references, It is belived that immunophenotype and TCR rearrangement are necessary means to diagnosis hepatosplenic gammadelta T cell lymphoma.
