Expression and significance of TGF-beta1, TbetaRII and c-myc in patients with acute leukemia.
- Author:
Hui SUN
1
;
Bin CHU
Author Information
1. Department of Hematology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. sunhui371@medmail.com.cn
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Adolescent;
Adult;
Aged;
Bone Marrow Cells;
metabolism;
Child;
Female;
Humans;
Immunohistochemistry;
Leukemia;
metabolism;
pathology;
Male;
Middle Aged;
Proto-Oncogene Proteins c-myc;
biosynthesis;
Receptors, Transforming Growth Factor beta;
biosynthesis;
Transforming Growth Factor beta1;
biosynthesis
- From:
Journal of Experimental Hematology
2005;13(4):567-569
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relationship between inactivation of TGF-beta signaling pathway and acute leukemia, the expressions of TGF-beta1, TbetaRII and c-myc in the bone marrow mononuclear cells were detected by S-P immunocytochemical staining. The results showed that no significant difference of TGF-beta1 exepression was found between the patients and the control (P > 0.05), the expression of TbetaRII was significantly lower in patients than in control (P < 0.05) and the expression of c-myc was significantly higher in patients than in control (P < 0.05). There was no significant difference of TGF-beta1, TbetaRII and c-myc exepression between acute nonlymphoid leukemia and acute lymphoid leukemia (P > 0.05). Expressions of TbetaRII and c-myc were negatively correlated (r = -0.474, P < 0.01). In conclusion, the leukemic cells escape from the growth inhibitory effect because of the inactivation of TGF-beta signaling pathway; downregulation of TGF-beta receptor II cause c-myc overexepression and leukemogenesis.
