Reference value of plasma N-terminal-pro-B-type natriuretic peptide in middle-aged and elderly Chinese
10.3760/cma.j.issn.0253-3758.2013.12.013
- VernacularTitle:我国中老年人N末端B型利钠肽原的正常参考值范围
- Author:
Xue-Juan JIN
1
;
Jing-Min ZHOU
;
Jun ZHOU
;
Yong YU
;
Xiao-Tong CUI
;
Jun-Bo GE
Author Information
1. 200032,复旦大学附属中山医院心内科 上海市心血管病研究所
- Keywords:
Natriuretic peptide,brain;
Reference values;
Middle aged;
Aged
- From:
Chinese Journal of Cardiology
2013;41(12):1045-1049
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the normal ranges for plasma N-terminal-pro-B-type natriuretic peptide (NT-proBNP) of middle-aged and elderly (≥40 years) healthy subjects in China.Methods A total of 5133 subjects (2170 men and 2963 women) from the cohort of Shanghai Heart Health Study (SHHS) were included in this study.Plasma NT-proBNP was measured by electrochemiluminescence immunoassay.The reference values (2.5th-97.5th quartiles) were determined using both empiric and quantile regression methods.Results Plasma NT-proBNP values were higher in women than in men at all respective age groups(all P ＜ 0.01),and natural log-transformed NT-proBNP values increased in proportion with age for both genders and there was a lineal correlation between natural log-transformed NT-proBNP values and age (all P ＜ 0.01).Quantile regression derived normal reference values for NT-proBNP in male were 4.5-86.8 ng/L in the 40-44 years old group,5.4-108.5 ng/L in the 45-49 years old group,6.6-135.5 ng/L in the 50-54 years old group,7.9-169.4 ng/L in the 55-59 years old group,9.6-211.7 ng/L in the 60-64 years old group,11.7-264.6 ng/L in the 65-69 years old group,14.2-330.7 ng/L in the 70-74 years old group,and 18.1-429.2 ng/L in the ≥75 years old group.The reference values in female for NT-pro-BNP in respective age group were 8.5-141.8 ng/L,10.4-166.6 ng/L,12.8-195.7 ng/L,15.7-229.9 ng/L,19.3-270.1 ng/L,23.7-317.3 ng/L,29.1-372.8 ng/L,and 35.7-451.9 ng/L.Conclusion This study preliminarily establishes the normal ranges of plasma NT-proBNP in middle-aged and elderly (≥40 years) Chinese.
