Plasma scavenger receptor B Ⅰ and CD36 expression change and susceptibility of atherosclerosis in patients post liver transplantation
10.3760/cma.j.issn.0253-3758.2014.02.008
- VernacularTitle:肝移植术后血清道夫受体-BⅠ和CD36表达变化与动脉粥样硬化
- Author:
Xin CHEN
1
;
Jinhong XUE
;
Shuyi ZHANG
;
Liying SUN
;
Chengzhi LU
Author Information
1. 300192,天津市第一中心医院心内科
- Keywords:
Liver transplantation;
Atherosclerosis;
Scavenger receptor
- From:
Chinese Journal of Cardiology
2014;42(2):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between expression changes of plasma macrophages scavenger receptor (SR)-B Ⅰ and CD36 and risk of arteriosclerosis in end-stage liver disease (ESLD) patients post liver transplantation.Methods A total of 20 liver transplantation patients were included.Clinical data including blood pressure,blood lipid,blood glucose,incidence of new-onset cardiovascular events were obtained.Plasma macrophages scavenger receptor SR-B Ⅰ and CD36 expressions were detected by polymerase chain reaction (RT-PCR) and Western-blot before and at 1 year after liver transplantation.Results The serum levels of TC [(5.34 ± 0.87) mmol/L vs.(4.27 ± 0.91) mmol/L],TG [(2.47±0.81)mmol/Lvs.(1.02±0.49)mmol/L] and LDL-C [(3.36±0.67)mmol/Lvs.(2.14± 0.74) mmol/L] were significantly increased (P ＜ 0.05) while the serum level of HDL-C [(0.98 ± 0.84) mmol/L vs.(1.58 ± 0.34) mmol/L] was significantly reduced (P ＜ 0.05) at 1 year post transplantation compared to before-transplantation levels.One patient developed non-ST segment elevation myocardial infarction and treated with percutaneous coronary intervention,another patient developed atrial fibrillation at one year after transplantation.The plasma mRNA expression of SR-B [was reduced (20.44 ± 0.60 vs.23.12 ±0.69,P ＜0.05) while the expression of CD36 mRNA was upregulated(20.91 ±0.35 vs.18.55 ± 0.62,P ＜ 0.05) at 1 year after liver transplantation compare with that of before the transplantation.Similarly,the plasma protein expression of SR-B Ⅰ was reduced (0.21 ± 0.13 vs.0.64 ± 0.28,P ＜ 0.05) while the protein expression of CD36 was upregulated (0.94 ± 0.13 vs.0.42 ± 0.19,P ＜ 0.05) at 1 year after liver transplantation compare with that of before the transplantation.Conclusion Plasma expression changes of SR-B Ⅰ and CD36 might contribute to the dyslipidemia and contribute to the atherosclerosis susceptibility after liver transplantation.
