Effects of acute hypoxia on plasma metabolome in mice.
- Author:
Yu-ping WANG
1
;
Chang-jiang GUO
;
Ji-jun YANG
;
Jing-yu WEI
;
Qi ZHANG
;
Xian-zhong YAN
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Altitude; Animals; Blood Proteins; metabolism; Energy Metabolism; physiology; Hypoxia; metabolism; physiopathology; Male; Metabolome; physiology; Metabolomics; methods; Mice; Random Allocation
- From: Chinese Journal of Applied Physiology 2009;25(2):177-180
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the metabolic effects of acute hypoxia on mice plasma.
METHODSFourteen mice were randomly divided into two groups: control and hypoxia group. The mice of hypoxia group were exposed to a simulated altitude of 6000 meters for 8 hours. Nuclear magnetic resonance spectrometer was used to identify the metabolic changes after acute hypoxia.
RESULTSCompared with control, the most notable significantly after acute hypoxia exposure. remarkably and lactate increased metabolic changes in plasma were as follows: camrnitine decreased levels of lipids and pyruvate, alanine, taurine, Decreases in levels of beta-HB, ethanol glycerol, glutamate, glycine and serine, and increased choline, glucose, and glutamine were also observed in hypoxia group.
CONCLUSIONSignificant changes in the plasma carbohydrate, lipid and amino acid profiles were observed following acute hypoxia, suggesting a hypoxia-induced alteration in energy and related substances metabolism.
