Activation of periphery group III metabotropic glutamate receptors inhibits formalin-induced activation of spinal p38-MAPK in rats.
- Author:
Xiao-chun YAN
1
;
Zhi-feng PENG
;
Xiao-rong YANG
;
Xin ZHAO
;
Nai-hong LIU
;
Xing JIN
;
Qiao CHENG
;
Ce ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Formaldehyde; Male; Nociception; physiology; Pain; chemically induced; metabolism; physiopathology; Phosphoserine; pharmacology; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; physiology; Spinal Cord; metabolism; physiopathology; p38 Mitogen-Activated Protein Kinases; metabolism
- From: Chinese Journal of Applied Physiology 2009;25(2):203-206
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the effects of periphery injection of L-SOP on the activation of p38MAPK in spinal cord in formalin pain model in rats.
METHODSFourty-eight male Wistar rats were divided randomly into four groups (n=12): NS group and three different dose of L-SOP groups. For each group, 6 rats used to observe flinching and licking time every as nociception behavior 3 minutes in 1 hour after formalin injected and the other 6 rats used to observe the activation of p38(P-p38) by Western blotting.
RESULTSAll the three different groups of L-SOP could inhibit nociception behavior in the tonic phase,and 250 nmoVl/L and 500 nmol/L groups could suppress not only in the tonic phase but also in the acute phase. 250 nmol/L and 500 nmol/L groups could reduce activated or phosphorylated p38MAPK in spinal cord.
CONCLUSIONPeriphery injection of L-SOP can reduce nociceptive behavior and phosphorylated p38MAPK in the spinal cord in formalin-induced hyperalgia, it is suggested that there is functional expression of mGluRs III in the periphery and is involved in the processing of peripheral noxious informations.
