Biomechanical properties of artery in spontaneously hypertensive rats after treating with tetrahydrobiopterin.
- Author:
Bao-liang ZHU
1
;
Shu-ling LIU
;
Mei-fang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arteries; physiopathology; Arteriolosclerosis; prevention & control; Biomechanical Phenomena; Biopterin; analogs & derivatives; therapeutic use; Hypertension; drug therapy; physiopathology; Male; Nitric Oxide Synthase; Random Allocation; Rats; Rats, Inbred SHR
- From: Chinese Journal of Applied Physiology 2009;25(3):325-328
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the effect of remodeling and biomechanical properties after chronic treating with tetrahydrobiopterin (BH4) in spontaneously hypertensive rats.
METHODSThe spontaneously hypertensive rat(SHR) were given with BH4 chronically. The opening angle in the zero-stress state , wall-to-lumen area ratios (W/L) of thoracic aorta and the relationship between pressure and diameter (P-D) of mesenteric artery were measured by computer image analysis in 4, 16, and 26 week-old respectively.
RESULTSTreating with BH4 chronically from 4 weeks-old in SHR, there was a significant decrease in morphometric parameters of the thoracic aorta and an increase in the zero-stress state of opening angle of elastic artery. The P-D curve of mesenteric artery moved upward.
CONCLUSIONTreating with BH4 prevented the structure and function of artery from abnormal changing, including to attenuate the resistant vascular hypertrophy and recover the vascular elasticity and expansibility.
