Effects of Honeysuckle flower and Scutellaria Baicalensis Georgi on constraction and electric activity of rabbit small intestine smooth muscle.
- Author:
Shi-jun SONG
1
;
Fang-fang LI
;
Ying XU
;
Li-hua ZHANG
;
Fang YUAN
;
Yi ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; drug effects; Animals; Depression, Chemical; Drugs, Chinese Herbal; pharmacology; Female; Flowers; chemistry; In Vitro Techniques; Intestine, Small; physiology; Lonicera; chemistry; Male; Muscle Contraction; drug effects; Muscle, Smooth; physiology; Rabbits; Scutellaria baicalensis; chemistry
- From: Chinese Journal of Applied Physiology 2009;25(3):344-348
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effect of Honeysuckle flower (HF) and Scutellaria Baicalensis Georgi (SBG) on contraction and electric activity of small intestine smooth muscle in rabbit and the underlying mechanisms.
METHODSUsing organ bath technique to observe the effect of HF and SBG on contractive and electric activity of small intestine smooth muscle in rabbit.
RESULTSHF and SBG significantly decreased the amplitude, frequency and area under the curve of contractive, as well as electric activity in a dose-depended manner. IC50 of the contractive amplitude was 6.30 g/L and 1.56 g/L by Logit Loglinear analysis. The inhibitive effect of HF and SBG on contractive activity could be partly decreased by beta-receptor blocker Propranolol, NO synthase inhibitor L-NAME, and K+ channel blocker Glibenclamide. Also HF and SBG inhibited acetylcholine-induced both intracellular and extracellular calcium-depended contraction significantly.
CONCLUSIONHF and SBG obviously inhibit the contractive and electric activity of small intestine smooth muscle of rabbit. The mechanisms are related to several pathways.
