Effects of inulae and ochrae decoction on the change of rabbits EGG and 5-HT resulted from chemotherapeutic drugs.
- Author:
Li-juan SHI
1
;
Jie GUAN
;
Hao TANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; adverse effects; Cisplatin; adverse effects; Drugs, Chinese Herbal; pharmacology; therapeutic use; Electromyography; drug effects; methods; Inula; chemistry; Nausea; chemically induced; drug therapy; Phytotherapy; Rabbits; Serotonin; metabolism; Stomach; metabolism; physiopathology; Vomiting; chemically induced; drug therapy
- From: Chinese Journal of Applied Physiology 2009;25(3):377-381
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the antagonism mechanism of inulae and ochrae decoction on toxicity damage of gastrointestinal tissue induced by DDP (cisplatin).
METHODSTwenty-four healthy hybrid rabbits were divided into three groups in random: the control group, DDP group, inulae and ochrae decoction + DDP group. The change of rabbits EGG, the concentration of 5-HT,5-HIAA of serum and the content of sinus ventriculi mucosa and the upper part of duodenum tissue were examined. Ultrastructure changes were observed by transmission electron microscope (TEM).
RESULTSThe EGG amplitude of DDP group was increased and the frequency was fast (P < 0.05) after i.v. DDP, meanwhile the concentration of 5-HT, 5-HIAA was increased (P < 0.05), and the content of sinus ventriculi mucosa and the upper part of duodenum tissue were higher than that of Inulae and Ochrae Decoction + DDP group (P < 0.05), and the change was seriously under the TEM observing; while inulae and ochrae decoction could prevent the change of EGG caused by DDP, showing the amplitude decreased, and the frequency was slow, and the concentration of 5-HT, 5-HIAA of serum and the content of tissue became lower than that of DDP group.
CONCLUSIONInulae and ochrae decoction could antagonize the change of EGG caused by DDP, which maybe have relations with the over-releasing of gastrointestinal 5-HT.
