Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats.
- Author:
Hong-yan ZHAO
1
;
Xin QIN
;
Yu CAO
;
Yu YANG
;
Shu-fen ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arginine Vasopressin; metabolism; Cyclic AMP; metabolism; Fever; metabolism; Hypothalamus; drug effects; metabolism; Male; Naloxone; pharmacology; Rats; Rats, Sprague-Dawley; Septum of Brain; drug effects; metabolism
- From: Chinese Journal of Applied Physiology 2009;25(3):408-410
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats.
METHODSThe fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected.
RESULTSNaloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01).
CONCLUSIONNaloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.
