Effects of CRF receptor antagonist on rem sleep in neonatal rat.
- Author:
Xue-dong LIU
1
;
Hong-kun FAN
;
Gui-hong ZHANG
;
Shu-chun WANG
;
Zhao ZHANG
;
Ping-fu FENG
Author Information
- Publication Type:Journal Article
- MeSH: Aniline Compounds; pharmacology; Animals; Female; Male; Polysomnography; Pyrimidines; pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; antagonists & inhibitors; Sleep, REM; drug effects; physiology; Wakefulness; drug effects; physiology
- From: Chinese Journal of Applied Physiology 2010;26(1):86-89
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the role of NB127914, a CRF R1 receptor antagonist, in the regulation of neonatal sleep/wake cycle.
METHODSRat pups were surgically implanted with electrodes at postnatal day(PN) 13. At PN 14, 6 hours polysomnographic recording data were continuously collected before and after administration of various doses of NBI 27914, atropine and the same amount of saline.
RESULTSCompared with baseline, rapid eye movement (REM) sleep was significantly reduced and was replaced primarily by non-REM (NREM) sleep in all groups treated with NBI, but not with dimethyl sulfoxide/saline. Atropine suppressed REM sleep significantly and increased wakefulness simultaneously.
CONCLUSIONBlockage of corticotropin-releasing factor (CRF) R1 receptors deprives neonatal rat REM sleep.
