The impact of diabetes mellitus and insulin interference on cortical SCF/KIT of mice.
- Author:
Luo YUN
1
;
Niu FENG-NAN
;
Zhu WEN-JING
;
Xu YUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cerebral Cortex; metabolism; Diabetes Mellitus, Experimental; drug therapy; metabolism; Down-Regulation; physiology; Insulin; therapeutic use; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-kit; metabolism; Stem Cell Factor; metabolism
- From: Chinese Journal of Applied Physiology 2010;26(1):94-96
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of cortical SCF/KIT system at different blood glucose level in mice.
METHODS27 male C57 mice were randomly divided into control group, diabetes group, and diabetes plus insulin group. The diabetic mice were induced by streptozotocin. Western-blot and double-immunofluorescence histochemistry were used to detect the expression of SCF and KIT.
RESULTSBoth methods indicate that the level of S-SCF and M-SCF were decreased significantly in the diabetes group, and this trend can be reversed effectively when the insulin was utilized.
CONCLUSIONThe decline of SCF might be one of underlying mechanisms of diabetic encephalopathy.
