Preparation and in vitro release characteristics of pulsed-release tablets of Apocynum venetum.
- Author:
Huasheng YANG
1
;
Fugui XIE
;
Yuewen YANG
;
Yongming LUO
Author Information
- Publication Type:Journal Article
- MeSH: Apocynum; chemistry; Delayed-Action Preparations; chemistry; Diffusion; Drug Compounding; methods; Drugs, Chinese Herbal; chemistry; In Vitro Techniques; Lactose; analogs & derivatives; analysis; Methylcellulose; analogs & derivatives; analysis; Osmotic Pressure; Plant Leaves; chemistry; Polymethacrylic Acids; analysis; Solubility; Tablets; chemistry; Time Factors
- From: China Journal of Chinese Materia Medica 2011;36(11):1427-1430
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEUsing Apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion, swelling, osmotic pressure mechanism and to evaluate the release characteristics.
METHODThe pulsatile release tablets were prepared by film coating methods using HPMC E5 and Eudragit The effect of formulation on pulsatile release of A. venetum was investigated.
RESULTThe pulsed-release tablet was prepared by a swelling layer coating which contains HPMC E5 and a controlled-release membrane containning Eudragit. The delayed release time of the tablets was (5.0 +/- 0.5) h.
CONCLUSIONThe pulsatile release characteristics of A. venetum pulsatile release tablets were confirmed in vitro.
