Chemical constituents of Halenia elliptica.
- Author:
Hongling WANG
1
;
Hao CHEN
;
Chang'an GENG
;
Xuemei ZHANG
;
Yunbao MA
;
Zhiyong JIANG
;
Jijun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acrolein; analogs & derivatives; analysis; isolation & purification; Chromatography; Dicarboxylic Acids; analysis; isolation & purification; Gentianaceae; chemistry; Iridoid Glycosides; isolation & purification; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oleanolic Acid; analysis; isolation & purification; Plant Extracts; isolation & purification; Sitosterols; analysis; isolation & purification; Xanthones; analysis; isolation & purification
- From: China Journal of Chinese Materia Medica 2011;36(11):1454-1457
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of Halenia elliptica.
METHODThe air-dried whole plants of Halenia elliptica were extracted with 90% EtOH. The EtOH extract was condensed to a small amount of volume and extracted with petroleum ether, EtOAc and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the EtOAc fraction, and identified based on spectral analyses (MS, 1H-NMR, 13C-NMR).
RESULT12 compounds were isolated from H. elliptica, and characterized as 8-hydroxy-2-methylchromone (1), 5-methoxy-2-methylchromone (2), 7-epi-vogeloside (3), coniferl aldehyde (4), sinapaldehyde (5), norbellidifolin (6), 1-hydroxyl-2,3,4,6-tetramethoxyxanthone (7), 1-hydroxyl-2,3,4,7-tetramethoxyxanthone (8), 1-hydroxyl-2,3,5-trimethoxyxanthone (9), together with azelaic acid, beta-sitosterol, and oleanolic acid.
CONCLUSIONCompounds 1, 2 were new natural compounds and compounds 3-6, 10 were obtained from H. elliptica for the first time and compound 6 showed inhibitory activities against HBsAg and HBeAg secretion with IC50 value of 0.77 and < 0.62 mmol x L(-1), respectively.
