Tissue distribution in mice of danshensu from sodium danshensu and Salvia miltiorrhiza injection.
- Author:
Juan WANG
1
;
Zhangqing MA
;
Zongyuan HONG
;
Jianguo SONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; pharmacokinetics; Female; Injections, Intraperitoneal; Kidney; chemistry; metabolism; Lactates; pharmacokinetics; Liver; chemistry; metabolism; Lung; chemistry; metabolism; Male; Mice; Myocardium; chemistry; metabolism; Plant Preparations; pharmacokinetics; Salvia miltiorrhiza; Spleen; chemistry; metabolism; Tissue Distribution
- From: China Journal of Chinese Materia Medica 2011;36(11):1516-1518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the concentration in mice of danshensu from sodium danshensu and Salvia miltiorrhiza injection and undertake comparative study of them as well as to assess the effect of other components of S. miltiorrhiza injection on the tissue distribution of danshensu.
METHODMice received intraperitoneal administration of sodium danshensu or S. miltiorrhiza injection (equal to danshensu 60 mg x kg(-1)) respectively, and was executed 30 minutes after administration. The concentration of danshensu in different tissues was separately determined by high performance liquid chromatographic method.
RESULTThe characteristic profiles of sodium danshensu in different tissues were C(kidney) > C(spleen) > C(lung) > C(heart) > C(liver). The characteristic profiles of danshensu from S. miltiorrhiza injection in different tissues were C(kidney) > C(lung) > C(spleen) > C(heart) approximately C(liver). The concentration of danshensu in S. miltiorrhiza injection in liver and kindey was higher than sodium danshensu itself.
CONCLUSIONIt was suggested that the other components in S. miltiorrhiza injection influent the distribution profile in tissues of danshensu.
