Experimental study on in vitro transdermal absorption of Shangshi Zhitong cataplasm.
- Author:
Xiaoru WU
1
;
Cheng HE
;
Naijie WANG
;
Yuanyuan ZHANG
;
Chunxia XI
;
Suhua XIE
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Alkaloids; pharmacokinetics; Animals; Atropine; pharmacokinetics; Drugs, Chinese Herbal; pharmacokinetics; Male; Mice; Rats; Rats, Wistar; Skin Absorption; Strychnine; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2012;37(7):913-915
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo conduct an experimental study on in vitro transdermal absorption of prepared Shangshi Zhitong cataplasm.
METHODFranz diffusing cells and mice were adopted for the percutaneous penetration study. The accumulative percutaneous permeation of total alkaloids, strychnine and atropine in certain time was determined by acid dye colorimetry and HPLC.
RESULTThe accumulative permeation of alkaloids (Q) increased with time (t), with a linear relation between them.
CONCLUSIONThe in vitro percutaneous penetration of Shangshi Zhitong cataplasm complies with the zero-order kinetics.
