Influence of different solutions on extracting of active components in Danggui Chishao drug pair.
- Author:
Wen DING
1
;
Dawei QIAN
;
Pei LIU
;
Jin'ao DUAN
;
Erxin SHANG
;
Yuping TANG
;
Jing WU
Author Information
- Publication Type:Journal Article
- MeSH: 4-Butyrolactone; analogs & derivatives; chemistry; Benzoates; chemistry; Benzofurans; chemistry; Bridged-Ring Compounds; chemistry; Chromatography, Liquid; Drugs, Chinese Herbal; chemistry; Gallic Acid; chemistry; Glucosides; chemistry; Hydroxybenzoates; chemistry; Mass Spectrometry; Monoterpenes; chemistry; Phthalic Acids; chemistry; Solvents; chemistry; Vanillic Acid; chemistry
- From: China Journal of Chinese Materia Medica 2012;37(7):916-919
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the dissolution rate of active components of different extracting solvents of Danggui Chishao drug pair.
METHODThe dissolution rates of phenolic acids (ferulic acid, vanillic acid and gallic acid), monoterpenes (gallic acid, peoniflorin, albiflorin, hydroxypeoniflorin and galloylpaeoniflorin) and phthalates (senkyunolide and ligustilide) contained in Danggui Chishao drug pair were determined by quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS) and ultra high performance liquid chromatography in combination with triple-quadrupole mass spectrometry (UPLC-TQ-MS).
RESULTThe dissolution rates of phenolic acids and monoterpenes decreased with the increase in alcohol concentration, on the contrary the rates of phthalates increased. The relative dissolution rates of most active components were relatively high in water and low concentration alcohol than other solvents.
CONCLUSIONLiquid chromatography-mass spectrometry is practical for comprehensive multi-component assessment on traditional Chinese medicine preparation processes and can provide reference for optimization of processing parameters.
