Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill.
- Author:
Yiwei WANG
1
;
Yujie LI
;
Yanli WANG
;
Weipeng YANG
;
Ying CHEN
;
Dong ZHANG
;
Qing YANG
;
Yingfeng ZHANG
;
Tao LI
;
Xiaoxin ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Berberine; metabolism; pharmacokinetics; Berberine Alkaloids; metabolism; pharmacokinetics; Drugs, Chinese Herbal; pharmacology; Evodia; chemistry; Intestinal Absorption; drug effects; Male; Rats
- From: China Journal of Chinese Materia Medica 2012;37(7):985-990
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation.
METHODUse L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka.
RESULTEvodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 3:1:3.
CONCLUSIONEvodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.
