Maternal-neonatal vitamin D status and related factors.
- Author:
Xue-ling ZHUANG
1
;
Zhi-wei ZHU
;
Dong-bo ZHU
;
Li-qin CHEN
;
Zheng-yan ZHAO
;
Jie SHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Calcium; blood; Dietary Supplements; Female; Fetal Blood; chemistry; metabolism; Humans; Infant, Newborn; blood; Male; Maternal Nutritional Physiological Phenomena; Nutritional Status; Pregnancy; blood; Pregnancy Complications; blood; prevention & control; Pregnancy Trimester, Third; Regression Analysis; Risk Factors; Seasons; Sunlight; Vitamin D; administration & dosage; analogs & derivatives; blood; Vitamin D Deficiency; blood; etiology; prevention & control; Young Adult
- From: Chinese Journal of Pediatrics 2012;50(7):498-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the relationship between maternal and neonatal vitamin D status and related factors.
METHODSerum 25-(OH)D levels were measured by ELISA in 499 pregnant women at 30 - 37 weeks gestation and in cord blood of their infants born at term (37 - 42 wk gestation) in Southeastern China at 28.9°N latitude. One-way analysis of variance (ANOVA) was used to explore maternal and neonatal vitamin D levels by season. Pearson linear and linear regression of partial correlation was used to analyze the relationship between maternal and neonatal 25-(OH) D levels. The multiple factors related to maternal vitamin D status was assessed by binary logistic regression.
RESULTThe levels of serum 25-(OH)D were (33.0 ± 13.4) nmol/L in mothers and (31.0 ± 12.5) nmol/L in their newborns. Serum 25-(OH)D < 50 nmol/L was shown in 88.8% of mothers and 91.2% of their neonates. Both maternal and neonatal 25-(OH)D levels varied with season (Ps = 0.000). Vitamin D level was the lowest in spring, with the 25-(OH)D concentration < 50 nmol/L in 98.6% of mothers and 99.3% of their neonates. The highest vitamin D level was presented in fall, but there were still 64.0% of mothers and 75.0% of neonates with 25-(OH)D < 50 nmol/L. Except for season, calcium-vitamin D supplement and intake of egg ≥ 600 g per week during pregnancy benefited to improve maternal vitamin D level [25-(OH)D ≥ 50 nmol/L] [OR = 2.3 (95%CI:1.0, 5.3), 3.4 (95%CI:1.2, 9.9) respectively]. There was a positive correlation between maternal and neonatal 25-(OH)D measures in the sample as a whole (r = 0.45, P = 0.000, N = 499), the correlation was of no statistical significance when maternal serum 25-(OH)D was ≤ 25 nmol/L.
CONCLUSIONHypovitaminosis D was common in late pregnant mothers and their newborns in southeastern China, especially in spring. Vitamin D supplement and intake of vitamin D-rich food were beneficial to improvement of maternal vitamin D level. There was a moderate and positive correlation between maternal and neonatal 25-(OH)D concentrations in this population. The correlation was lost when maternal serum 25-(OH)D ≤ 25 nmol/L.
