Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina
10.3321/j.issn:0253-3758.2008.09.010
- VernacularTitle:他汀类药对氯吡格雷抗血小板作用的影响
- Author:
Jie SHEN
1
;
Rui-Yan ZHANG
;
Qi ZHANG
;
Zhen-Kun YANG
;
Jian HU
;
Jian-Sheng ZHANG
;
Ai-Fang ZHENG
;
Xian ZHANG
;
Wei-Feng SHEN
Author Information
1. 上海交通大学医学院附属瑞金医院
- Keywords:
Coronary disease;
Platelet aggregation;
Adenosine diphosphate;
Stafina;
Clopidogrel
- From:
Chinese Journal of Cardiology
2008;36(9):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective This prospective registered study was conducted to investigate the impact of statins (pravastatin,fluvastatin,atorvastatin) on clopidogrel platelet inhibition in patients with acute coronary syndrome (ACS) or stable angina.Methods A total of 1015 consecutive patients with ACS or stable angina underwent coronary angiography/percutaneous coronary intervention (PCI) were allocated to pravastatin group (n=228),fluvaatatin group(n=179),atorvastatin group(n=481)or placebo control group(n=127).Baseline characteristics,coronary angiography/PCI features and acute stent thrombosis,platelet aggregation induced by 2,5,10 and 20 mol adenosine diphosphate(ADP)at 1 minute(ADP-1),5 minutes (ADP-5)and maximal platelet aggregation (ADP-M) were compared among groups.Results Baseline and procedural characteristics were comparable among the four groups.Acute stent thrombosis (pravastatin group 0.9%,fluvastatin group 1.1%,atorvastatin group 1.0% and control group 0.8%,all P>O.05),ADP-1,ADP-5,and ADP-M (all P>0.05) were also similar among groups.Multivariate liner and ordinal logistic analysis revealed that age(B=0.21,P=O.001),dose of clopidogrel(B=7.30,P=0.002) and abe of low-molecular heparin (OR=6.71,P=0.01) were independent factors for platelet aggregation inhibition efficacy by clopidogreL Condusion Inhibition of platelet aggregation with clopidogrel was influenced by age,clopidogrel dose and low-molecular heparin but not by various stafin treatments.
