Effects of telmisartan on endoplasmic reticulum stress induced cardiomyocyte apoptosis in abdominal aortic banded rats
10.3321/j.issn:0253-3758.2008.09.017
- VernacularTitle:替米沙坦对腹主动脉缩窄大鼠内质网应激相关的心肌细胞凋亡的影响
- Author:
Jia-Rong TANG
1
;
Xiao-Ni YAN
;
Chang-Qing ZHOU
;
Li NI
;
Jin-Jie HOU
;
Dao-Wen WANG
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
Telmisartan;
Myocytes,cardiac;
Apoptosis;
Endoplasmic reticulum;
Stess
- From:
Chinese Journal of Cardiology
2008;36(9):838-842
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of telmisartan on endoplasm retiedum (ER) stress signal pathways and eardiomyocyte apoptosis in abdominal aortic banded rats.Methods Male SD rats were randomly divided into sham-operated group,abdominal aortic banding group(AAB)and AAB+telmisartan (5 mg·kg-1·d-1 per gavage,beginning at l week before AAB for 8 weeks,n=10 each).Ten weeks post AAB,hemodynamie measurements were performed,whole heart and left ventricular weights were obtained. Cardiomyocyte apoptosis was measured by TUNEL method.Myocardial GRP78 and CHOP protein expresssions were detected by Western blot and immunohistochemistry.Results The ratio of left ventricular weight to body weisht,the ratio of heart weight to body weisht,left ventrieular end diastolic pressure and the apoptosis index were significantly increased while left ventfieular end systolic pressure and±dp/dtmax were significantly decreased in AAB group than those in sham-operated group (all P<0.01),these changes could be significantly attenuated by telmisartan (all P<0.01).Moreover,myocardial GRP78 and CHOP expressions were significantly upregulated in AAB group than those in sham-operated group and telmisartan could significantly downregulate the increased GRfp78,CHOP expressions (all P<0.01).Conclusions Increased ER stress might be responsible for enhanced eardiomyocyte apoptosis in AAB rats.Telmisartan effectively attenuated the cardiomyocyte apoptosis and cardiac hypertrophy in AAB rats possibly through reducing ER stress.
