The efficacy of tetramethylpyrazine-eluting stents on inhibiting neointima formation in porcine coronary arteries
10.3321/j.issn:0253-3758.2008.09.018
- VernacularTitle:川芎嗪药物涂层支架预防猪冠状动脉再狭窄的实验研究
- Author:
Li-Juan CHEN
1
;
Yi FENG
;
Shu DING
;
Cheng-Xing SHEN
;
Zhong CHEN
;
Xuan LI
;
Gen-Shan MA
Author Information
1. 东南大学附属中大医院
- Keywords:
Coronary restenosis;
Stents;
Tetramethylpyrazine
- From:
Chinese Journal of Cardiology
2008;36(9):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the mechanism and efficacy of tetramethylpyrazine-eluting stents (TES) on inhibiting neointima formation in porcine coronary artefies.Methods TES was prepared by tetramethylpyrazine spray-coated in bare metal stents(BMS).Pigs were implanted with TES or BMS(n=7 each),respectively.Quantitative coronary angiography(QCA)and intravascular ultrasound (IVUS) were performed before,immediately after stenting and at 28 days after stenting.Coronary arteries segments (5 cm) before and post stenting area (5 cm) as well as at stenting location were harvested at 28 days post stenting for histopathological examinations(inflammation,vascular smooth muscle cells proliferation and apoptosis).Results Follow up QCA at 28 days showed that percentage diameter stenosis were significandy lower in the,TES group than that in the BMS group[(10.0±2.1)%VS (60.2±23.5)%.P=0.01].Tlle lumen area determined by IVUS was similar between the two groups and there was no in-stent thrombosis in TES or BMS treated animals.Internal elastic lamina area was significantly largerwhile the neointimal ares [(1.51±0.45)mm2 vs(4.60±1.39)mm2,P=0.04] Was significantly smaller in the TES group than that in the BMS group.Histopathologieal assessments showed fewer inflammatory cells in the stented-coronary artery walls than those at the border zones of stenting in both groups.The number of proliferating cells were significantly decreased while apoptotic cells were significantly increased in the TES group compared with the BMS group (all P<0.05).Conclusion TES could effectively reduce in.stent restenosis in this porcine model by attenuating Vascular smooth muscle proliferation and enhancing vascular smooth muscle apoptosis post stenting.
