Fenofibrate improves energy metabolism and attenuates isoproterenol induced acute myocardial ischemic injury in rats via PPAR α activation
10.3321/j.issn:0253-3758.2008.09.019
- VernacularTitle:非诺贝特与大鼠急性缺血性损伤心肌的能量代谢
- Author:
Jie YUAN
1
;
Jian WU
;
Zhi-Gang HAN
;
Xue-Kuan ZHONG
;
Ling-Wang ZHOU
;
Bo YU
Author Information
1. 哈尔滨医科大学附属第二医院
- Keywords:
Myocardial ischemia;
Procetofen;
Energy metabolism;
Isopmterenol
- From:
Chinese Journal of Cardiology
2008;36(9):847-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of peroxisome pmliferator-activated receptor(PPAR)α agonist Fenofibrate (FF) on energy metabolism and histology in isoproterenol (Iso) induced acute myocardial ischemie injury modeL Methods Male Wistar rats were randomly divided into control group.Iso group(5 ms/kg,I.p) and FF group (80 mg·kg-1·d-1 per gavage for 7 days,then Iso 5 mg/ks,I.p.n=30 each).Twenty-four hours post Iso,heart weight/body weight ratio,myocardial histopathological changes (HE staining),serum and myocardial free fatty acids(FFA)levels,the myocardial protein expression of PPAR (Westem blot) were determined.Result Compared with the control group,pathological myocardial injuries were observed under light microscope in Iso treated hearts and FF pretreatment could significantly attenuate these changes [necrotic area:O VS(10.004±3.00)% VS(7.36±2.60)%],the heart weight/body weight ratio,FFA in serum (501.17±43.69 VS 939.53±69.51 v8 736.53 4±70.30 mol/L)and myocardium(62.01±9.19 VS 140.59 4±19.34 VS 116.28 4±14.03 mol/L) were significantly increased while myocardial protein expressions of PPAR (251.57 4±10.95 VS 191.97±10.74 VS 215.08±9.61) was significantly downregulated in the Iso group and FF pretreatment could significantly attenuate these changes (all P<0.05).Condusion Our data suggested that the FFA utilization wag decreased in Iso induced acute myocardial ischemic injury and FF could attenuate Iso induced myocardial damage via activating PPAR signaling pathway.
