Association between plasma macrophage migration inhibitory factor concentration and coronary artery lesion severity
10.3321/j.issn:0253-3758.2008.10.012
- VernacularTitle:巨噬细胞游走抑制因子及其下游信号通路血浆水平与冠状动脉病变程度的相关性
- Author:
Li-Xia YANG
1
;
Rui-Wei GUO
;
Feng QI
;
Gui-Hua MIAO
;
Xian-Mei WANG
;
Yan-Kun SHI
;
Ming-Qiu LI
Author Information
1. 成都军区昆明总医院
- Keywords:
Coronary disease;
Macrophage migration-inhibitory factor;
Matrix metalloproteinase-9;
Activator protein-1
- From:
Chinese Journal of Cardiology
2008;36(10):912-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the plasma macrophage migration inhibitory factor(MIF),activator protein-1 (AP-1) and MMP-9 concentrations and the severity of coronary artery lesions in coronary heart disease (CHD) patients.Methods Patients were divided into normal controls (n=35),stable angina pectoris (SAP,n=32) and acute coronary syndrome (ACS,n=75)according to the coronary angiography (CAG),clinical and laboratory examinations.The CAG severity and extent of coronary lesions were analyzed by means of Gensini coronary score system.Enzyme linked immunosorent assay was used to measure the plasma MIF,AP-1 and MMP-9 concentrations.Results Plasma MIF,AP-1 and MMP-9 concentrations were significant increased in CHD patients [MIF:(14.97±2.11)μg/L,AP-1:1.43±0.33,MMP-9:(1.48±0.14)μg/L] compared to those in control group [MIF:(9.07±1.28) μg/L,AP-1:0.71 ±0.13,MMP-9:(1.01±0.07) μg/L,all P＜0.05].The MIF,AP-1 and MMP-9 concentrations in ACS group [MIF:(16.66±2.56) μg/L,AP-1:1.56±0.22,MMP-9:(1.58±0.14) μg/L] were also significant higher than those in SAP group[MIF:(11.01±2.12) μg/L,AP-1:1.04±0.25,MMP-9:(1.25±0.07) μg/L,all P＜0.05] and there was significant positive correlation between MIF,AP-1 and MMP-9 concentrations and the Gemini score of coronary artery lesions (all P＜0.05).AP-1 was positively correlated with MMP-9 in CHD patients (P＜0.05).Conclusions Plasma MIF,AP-1 and MMP-9 concentrations were positively correlated to the severity of coronary lesions in CHD patients.Higher MIF,AP-1 and MMP-9 concentrations in ACS patients than in SAP patients might suggest higher plaque instability in ACS patients.
