Assessment of therapeutic effects of stem cell transplantation in heart failure patients with old myocardial infarction by magnetic resonance imaging
10.3321/j.issn:0253-3758.2008.11.004
- VernacularTitle:磁共振成像对冠心病陈旧性心肌梗死所致心功能不全的诊断及干细胞移植疗效评价的应用
- Author:
Min-Jie LU
1
;
Shi-Hua ZHAO
;
Sheng LIU
;
Pu-Hong ZHANG
;
Shi-Liang JIANG
;
Yan ZHANG
;
Chao-Wu YAN
;
Qiong LIU
;
Jian LING
;
Lian-Jun HUANG
;
Zuoxiang HE
;
Minfu YANG
;
Shengshou HU
Author Information
1. 中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院
- Keywords:
Myocardial infarction;
Magnetic resonance imaging;
Stem cells transplantation
- From:
Chinese Journal of Cardiology
2008;36(11):969-974
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects of stem cell transplantation in heart failure patients with old myocardial infarction (OMI) by MRI.nethods Hcart failure patients [NYHA 2.7±0.7,male=18,mean age (59.5±10.1) Y] with OMI were randomly divided into 2 groups (group A:CABG+stem cell transplantation,group B:CABG;n=10 each).Left ventricular (LV) function was measured by MRI,viable myoeardium was detected by 18F-FDG myocardial metabolism imaging and late contrast-enhanced at baseline and 6 months post intervention.Results LVEF and LVEDV at baseline for group A were (20.71±6.09)% and (172.73±32.74) ml,and for group B were (27.59±2.31)% and (155.13±28.36)ml,respectively (P＞0.05).The LVEF was equally improved in group A and B (mean 8.63% vs.10.37%,P＞0.05) while ALVEDV was significant higher in group A than that in group B [(9.91±39.50)ml vs.(-22.34±31.35)ml.P＜0.05].Ventricular wall thickening ratio at 6 months post intervention was significantly higher in group A than that in group B[(11.40 ±11.53)% vs.(2.27±7.20)%,P＜0.05].Late contrast-enhanced M RI results correlated with 18F-FDG myocardial metabolism imaging SPECT well in assessment of myocardial viability (kappa value:0.446,P＜0.001;sensitivity:68.3% and specificity:92.5%).Conclusions Stem cell therapy on top of CABG aggravated LV remodeling in heart failure patients with old myocardial infarction.The specificity of MRI Is similar to 18F-FDG SPECT while the sensitivity is inferior to 18F-FDG SPECT on detecting viable myocardium.
