Comparison of coronary plaque composition between patients with acute coronary syndrome and stable coronary artery disease
10.3321/j.issn:0253-3758.2008.11.009
- VernacularTitle:急性冠状动脉综合征与稳定性冠心病斑块组织成分的比较
- Author:
Tian-Song WANG
1
;
Xin-Ming LI
;
Shao-Wei ZHUANG
;
Bei TIAN
;
Can JIN
;
Sheng WANG
;
Bin LI
;
Cong-Xin HUANG
Author Information
1. 同济大学附属上海东方医院
- Keywords:
Coronary arteriosclerosis;
Uhrasonography,interventional
- From:
Chinese Journal of Cardiology
2008;36(11):994-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of the present study was to compare the plaque composition between patients with acute coronary syndrome (ACS) and stable coronary artery disease (SCAD) by intravascular ultrasound virtual histological analysis.Methods Two hundred and ten patients were divided into ACS group (n=131,188 diseased vessels) and SCAD group (n=79,158 diseased vessels).A total of 346 de novo lesions with＞50% stenosis in native coronary arteries with diameters＞2.5 mm were studied with intravascular ultrasonography,Geometric and compositional data were obtained using intravascular ultrasound virtuai histology software.Results There were no significant difierences in overall lesions for fibrous (51.2%±12.5% vs.52.6%±9.6%),fibrolipidic (11.3%±10.6%vs.12.9%±9.4%),calcium (15.1%±8.9% vs.20.5%±12.5%) or necrotic core (23.1%±9.8% vs.20.4%±6.8%,all P＞0.05) components between ACS and SCAD patients.Culprit lesions for fibrous (49.1%±11.2% vs.50.3%±9.7%),fibrolipidic (10.2%±9.5% vs.12.7%±9.5%),calcium (15.4%±8.9% vs.17.4%±24.8%),or necrotic core (24.O%±11.5% vs.19.7%±5.3%,all P＞0.05)cornponents were also similar between ACS and SCAD patients.High density lipoprotein-cholesterol (HDL) levels＞1.04 mmol/L was associated with more fibrolipidic (15.6%±9.6% vs.7.4%±5.9%) and less necrotic core (19.4%±8.6% vs.28.6%±11.2%.all P＜0.05 vs.patients with HDL≤1.04 mmol/L) cornponents in ACS patients.Conclusion Coronary plaque composition was similar between ACS and SCAD patients.
