Association between hypertensive left ventricular hypertrophy and cardiovascular events in adult Beijing residents:a cohort study
10.3321/j.issn:0253-3758.2008.11.018
- VernacularTitle:北京地区25～64岁人群高血压左心室肥厚与心血管事件和死亡的关系
- Author:
Yan LI
1
;
Dong ZHAO
;
Jing LIU
;
Cui-Fen LI
;
Wei GUO
;
Chi-Hong CHEN
;
Peng HAO
;
Jia-Yi SUN
;
Lan-Ping QIN
;
Wei WANG
Author Information
1. 首都医科大学附属北京安贞医院(北京市心肺血管疾病研究所)
- Keywords:
Hypertension;
Hypertrophy,left ventricular;
Cardiovascular disease;
Prospective study
- From:
Chinese Journal of Cardiology
2008;36(11):1037-1042
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the impact of hypertensive left ventricular hypertrophy (LVH) on cardiovascular events (CVD) in adult Beiiing residents.Methods CVD risk factor survey was conducted in 7023 Beijing residents aged 25-64 by a stratified-random sample design from 1984 to 1993 in three years interval.CVD events were followed up and the association of the hypertensive LVH and risk of CVD and total death was analyzed by multivariable Cox Regression Model.All subjects were followed up to December 2004.Results There were 211 non hypertensive LVH patients in the cohort and were excluded from the study.(1)There were 2240 hypertensive patients among 6812 subjects on baseline.The total prevalence of LVH was 11.8% (16.1% in male and 7.5% in female).(2) Compared to the group with normal blood pressure and without left ventricular hypertrophy,subjects with hypertensive LVH had significantly higher risk for acute coronary,acute stroke,total CVD and total death rate.The relative risks (RR) were 4.92(95% CI:2.3,10.7),4.2(95% CI:2.6,7.0),4.1(95% CI:2.6,6.3) and 3.3(95% CI:2.0,5.3),respectively.(3) Compared to the group with hypertension and without LVH,the group with hypertensive LVH had also significantly higher risk for acute stroke,total CVD and total death rate.The RR were 1.8 (95%CI:1.1,2.8),1.7(95% CI:1.2,2.3) and 1.7 (95% CI:1.1,2.7),respectively.(4) The population attribute risks (PAR) of hypertensive LVH to the incidents of acute CHD,acute stroke,total CVD and total death were 13.0%,11.0%,10.4% and 7.9%,respectively.Conclusions Hypertensive left ventricular hypertrophy was an independent risk factor for long term risk of cardiovaseular events and death.
