Analysis of measles immunity level in persistent populations in Beijing, 2012.
- Author:
Juan LI
1
;
Li LU
;
Meng CHEN
;
Fang HUANG
;
Yang ZENG
;
Xiao-mei LI
;
Rui MA
;
Jing-bin PAN
;
Mu SUN
;
Hao SUN
;
Zhong-zhan WANG
;
Fang-ru GUO
;
Yi-hua ZHANG
;
Feng-shuang WANG
;
Tao WU
;
De-jun CUI
;
Xing-hui PENG
;
Jiang WU
2
;
Xing-huo PANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Antibodies, Viral; blood; Child; Child, Preschool; China; epidemiology; Female; Humans; Infant; Male; Measles; epidemiology; immunology; prevention & control; Measles virus; Young Adult
- From: Chinese Journal of Preventive Medicine 2013;47(10):916-919
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the measles immunity level of persistent population in Beijing.
METHODSA total of 2125 objects from 10 age groups, who had been living in Beijing for over 6 months, were selected from urban and rural areas in Beijing in 2012. Demographic characteristics, history of measles and vaccine immunization were investigated by questionnaire. 5 ml blood sample of each subject was collected, and the Measles IgG antibody was measured by ELISA assay.
RESULTSPositive rate of measles antibody was 84.71% (1800/2125) and standardized positive rate was 88.07% . Median of antibody was 960.46 IU/L. Positive rate and median of measles antibody were significantly different between population from different age groups (χ(2) = 341.60, P < 0.01; H = 216.27, P < 0.01). Antibody positive rate and median were lowest in the <1 year age group, which were separately 43.06% (90/209) and 185.80 IU/L; and highest in the 1-4 (97.31% (181/186) and 2448.81 IU/L) and 5-9 years age group (96.46% (218/226) and 1910.72 IU/L). The range of antibody positive rate and median in adults of ≥ 15 years were 81.98%-90.14% and 744.38-1474.84 IU/L. Antibody positive rate and median in persistent population, which were separately 82.45% (883/1071) and 899.82 IU/L, were lower than those in migrant population, which were 87.00% (917/1054) and 166.19 IU/L, respectively (χ(2) = 8.51, P < 0.01;U = 538 704.00, P < 0.01). Antibody positive rate and median in population with vaccination history, which were separately 91.95% (891/969) and 1443.11 IU/L, were higher than those population without vaccination history and people whose history unknown (32.95% (57/173) , 127.33 IU/L; 86.67% (852/983) , 923.73 IU/L). The difference showed statistical significance (χ(2) = 399.92, P < 0.01; H = 202.11, P < 0.01).
CONCLUSIONAmong the persistent population in China, measles antibody level among the children aging 1-9 years old was high enough to prevent outbreak and epidemic of measles. However, we should try our best to strengthen the measles antibody level among the babies younger than 1 year old and the migrant population aging between 15 and 40 years old.