Improvements of lentiviral vector and its application in gene therapy of hematological diseases.
- Author:
Hong-Hu ZHU
1
;
Kai-Lin XU
Author Information
1. Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China.
- Publication Type:Journal Article
- MeSH:
Fanconi Anemia;
therapy;
Genetic Therapy;
Genetic Vectors;
genetics;
HIV-1;
genetics;
Hematologic Diseases;
therapy;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
metabolism;
Hemophilia A;
therapy;
Humans;
Lentivirus;
genetics;
Leukemia;
therapy;
beta-Thalassemia;
therapy
- From:
Journal of Experimental Hematology
2003;11(2):208-212
- CountryChina
- Language:Chinese
-
Abstract:
As lentiviral vector holds the characteristics of higher transfection to non-dividing cells, larger capacity of transfer gene fragments, long-term expression of therapeutic gene and lower rate of immunological response, therefore it becomes potential viral vector in gene therapy. Improvements of lentiviral vector, human immunodeficiency virus type-I as example, and its application in gene transfer for gene therapy of hematological diseases are emphasized in this review.
