Association of HLA-DPB1 alleles with chronic myelogenous leukemia in southern Chinese Hans.
- Author:
Hong TIAN
1
;
Shu-Yun ZHOU
;
Ze-Huan LIU
;
Yong-Gui FU
;
Feng-Juan LU
;
Jiang-Hai LIN
;
An-Long XU
Author Information
1. Department of Hematology, Nanfang Hospital, The First Military Medical University, Guangzhou, 510515, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Chi-Square Distribution;
China;
Gene Frequency;
Genotype;
HLA-DP Antigens;
genetics;
HLA-DP beta-Chains;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
genetics
- From:
Journal of Experimental Hematology
2003;11(3):266-268
- CountryChina
- Language:Chinese
-
Abstract:
To clarify the association between HLA-DPB1 alleles and chronic myelogenous leukemia (CML) in South Chinese, the allelic types of HLA-DPB1 were detected by sequence based typing (SBT) in 86 patients with CML and 82 healthy individuals from Southern China. The results showed that the frequencies of HLA-DPB1 * 1301 and DPB1 * 20011 were higher in patients with CML in comparison with those of healthy individuals. It is concluded that positive association may exist between certain HLA-DPB1 alleles and CML.
