CD4(+)CD25(+) regulatory T cells and their function in maintaining transplantation tolerance.
- Author:
Rui-Xiang FU
1
;
De-Pei WU
Author Information
1. The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Suzhou 215006, China.
- Publication Type:Journal Article
- MeSH:
CD4 Antigens;
blood;
CD8 Antigens;
blood;
Cell Division;
immunology;
Humans;
Interferon-gamma;
blood;
Interleukin-2;
blood;
Receptors, Interleukin-2;
blood;
T-Lymphocytes;
cytology;
immunology;
metabolism;
Transplantation Tolerance;
immunology
- From:
Journal of Experimental Hematology
2003;11(3):321-324
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews that as a functionally and phenotypically distict immunoregulatory T cell subpopulation, CD4(+)CD25(+) regulatory T cells can suppress the activation and proliferation of CD4(+)CD25(-) T cells and CD8(+) T cells and the production of IL-2 and IFN-gamma. These regulatory cells play an important role in allograft tolerance, although the mechanisms are not completely understood to date. CD4(+)CD25(+) regulatory T cells can be isolated, activated and expanded in vitro without loss of their immunoregulatory function. The suppressive function of activated CD4(+)CD25(+) cells is antigen non-specific. Ex vivo activated and expanded regulatory T cells have a perspective for practical use.
