Effects of compound danshen tablet on the expression of Abeta in transgenic cell model of Alzheimer's disease.
- Author:
Hua HU
1
;
De-sheng ZHOU
;
Rong YU
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; genetics; metabolism; Amyloid beta-Peptides; metabolism; Animals; Cell Line; Drugs, Chinese Herbal; pharmacology; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; chemistry; Transgenes
- From: Chinese Journal of Integrated Traditional and Western Medicine 2012;32(12):1663-1666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Compound Danshen Tablet (CDT) on the expression of the beta-amyloid peptide (Abeta) in transgenic cell model of Alzheimer's disease (AD).
METHODSThe previously successfully cultured transgenic cell model was used as AD transgenic cell model. Rats were fed with 0.5, 1, 2, and 4 times CDT. The AD transgenic cells were cultured in 0.5, 1, 2, and 4 times rats' sera. The expressions of Abeta in transgenic cells were detected using Western blot.
RESULTSThe optimal dose effect was obtained in the 1 time CDT group at 24 h.
CONCLUSIONCDT could reduce the Abeta expression level in the AD transgenic cell model.
